Tocris/G-1/3577/10/10毫克-免疫在线蚂蚁淘旗下平台

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Tocris/G-1/3577/10/10毫克

商品编号： 3577/10

品牌： Tocris Bioscience

市场价： ¥3780.00

美元价： 2268.00

产地：美国(厂家直采)

公司：

产品分类：受体

公司分类： Receptors

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:PotentandselectiveGPERagoNIST

ChemicalName:(±)-1-[(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]-ethanone

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveGPERagonist(K_i=11nM,EC₅₀=2nM);displaysnoactivityatERαandERβatconcentrationsupto10μM.IncreasescytosolicCa²⁺andinhibitsmigrationofSKBr3cellsandMCF-7cellsinresponsetochemoattractants(IC₅₀valuesare0.7and1.6nMrespectively)invitro.BlocksMCF-1cellcycleprogressionattheG₁phase.DisplaystherapeuticeffectsinthemouseEAEmodelofmultiplesclerosis.

TechnicalData

M.Wt	412.28
Formula	C₂₁H₁₈BrNO₃
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	881639-98-1
PubChemID	5322399
InChIKey	VHSVKVWHYFBIFJ-HKZYLEAXSA-N
Smiles	CC(C5=CC([C@@]4([H])[C@@]([H])3CC=C4)=C(C=C5)N[C@H]3[C@]1=CC(OCO2)=C2C=C1Br)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	41.23	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight412.28.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.43mL	12.13mL	24.26mL
5mM	0.49mL	2.43mL	4.85mL
10mM	0.24mL	1.21mL	2.43mL
50mM	0.05mL	0.24mL	0.49mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

TechnicalData

SolubilityData

PreparingStockSolutions

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