Biological Activity
Potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal membranes).
Technical Data
| M. Wt | 487.51 |
| Formula | C28H34N2O.2HCl |
| Storage | Desiccate at -20°C |
| CAS Number | 67469-81-2 |
| PubChem ID | 11957553 |
| InChI Key | NQWRSILGEXNJIT-UHFFFAOYSA-N |
| Smiles | Cl.Cl.C(CN1CCN(CCOC(C2=CC=CC=C2)C2=CC=CC=C2)CC1)CC1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.44 | 5 |
Preparing Stock Solutions
The following data is based on the product molecular weight 487.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.05 mL | 10.26 mL | 20.51 mL |
| 5 mM | 0.41 mL | 2.05 mL | 4.1 mL |
| 10 mM | 0.21 mL | 1.03 mL | 2.05 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.41 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Andersen et al (1987) Biochemical and pharmacological characterization of [3H]GBR 12935 binding in vitro to rat striatal membranes: labelling of the dopamine uptake complex. J.Neurochem. 48 1887 PMID: 2952763
Reith et al (1994) GBR 12909 and 12935 block dopamine uptake into brain synaptic vesicles as well as nerve endings. Eur.J.Pharmacol. 253 175 PMID: 8013544
Reith et al (1992) Evidence for mutually exclusive binding of cocaine, BTCP, GBR 12935, and dopamine to the dopamine transporter. Eur.J.Pharmacol. 227 417 PMID: 1446712
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