Biological Activity
A potent inhibitor of dopamine uptake (IC50 = 40 nM). Centrally active following systemic administration in vivo.
Technical Data
| M. Wt | 521.48 |
| Formula | C28H30F2N2O.2HCl |
| Storage | Desiccate at RT |
| CAS Number | 67469-45-8 |
| PubChem ID | 24978531 |
| InChI Key | ZBSZWEYIIGLGSX-RDRKJGRWSA-N |
| Smiles | FC(C=C2)=CC=C2C(OCCN3CCN(C/C=C/C4=CC=CC=C4)CC3)C1=CC=C(F)C=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 5 mM in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 521.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.92 mL | 9.59 mL | 19.18 mL |
| 5 mM | 0.38 mL | 1.92 mL | 3.84 mL |
| 10 mM | 0.19 mL | 0.96 mL | 1.92 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
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References
References are publications that support the products' biological activity.
Heikkila et al (1984) Behavioural properties of GBR12909, GBR13069 and GBR13098: specific inhibitors of dopamine uptake. Eur.J.Pharmacol. 103 241 PMID: 6237922
Mayer et al (1986) Prevention of the nigrostriatal toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by inhibitors of 3,4-dihydroxyphenylethylamine transport. J.Neurochem. 47 1073 PMID: 3489072
Van der Zee and Hespe (1985) Interaction between substituted 1-[2-diphenylmethoxyethyl]piperazines and dopamine receptors. Neuropharmacology 24 1171 PMID: 4094653
Keywords: GBR 13069 dihydrochloride, supplier, Potent, dopamine, reuptake, inhibitors, inhibits, DAT, Transporters, Monoamine, Neurotransmitter, GBR13069, dihydrochloride, Dopamine, Transporters, Dopamine, Transporters, Tocris Bioscience
