Tocris/GGTI 298/2430/1/1 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/GGTI 298/2430/1/1 mg

Tocris/GGTI 298/2430/1/1 mg

商品编号： 2430/1

品牌： Tocris Bioscience

市场价： ¥3700.00

美元价： 2220.00

产地：美国(厂家直采)

公司：

产品分类：其它酶

公司分类： Other_enzymes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:GeranylgeranyltransferaseI(GGTaseI)inhibitor

ChemicalName:N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-(1-naphthalenyl)benzoyl]-L-leucinemethylestertrifluoroacetatesalt

Purity:≥95%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

CAAZpeptidomimeticgeranylgeranyltransferaseI(GGTaseI)inhibitor.StronglyinhibitstheprocessingofgeranylgeranylatedRap1AwithlittleeffectonprocessingoffarnesylatedHa-Ras(IC₅₀valuesare3and>10μMrespectively).CausesG₀-G₁cellcycleblockandapoptosisinA549cellsandinhibitscellinvasionandmigrationinCOLO320CMcells.

TechnicalData

M.Wt	593.66
Formula	C₂₇H₃₃N₃O₃S.CF₃CO₂H
Storage	Storeat-20°C
Purity	≥95%(HPLC)
CASNumber	1217457-86-7
PubChemID	16078971
InChIKey	WALKWJPZELDSKT-UFABNHQSSA-N
Smiles	SC[C@H](N)CNC1=CC=C(C(N[C@H]([C@@](OC)=O)CC(C)C)=O)C(C2=CC=CC3=C2C=CC=C3)=C1.FC(F)(C(O)=O)F

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	14.84	25

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight593.66.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.68mL	8.42mL	16.84mL
5mM	0.34mL	1.68mL	3.37mL
10mM	0.17mL	0.84mL	1.68mL
50mM	0.03mL	0.17mL	0.34mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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TechnicalData

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