Biological Activity
Binds with high affinity to MT3 melatonin sites in hamster brain, and low affinity (and no efficacy) at MT1 and MT2 melatonin receptors and thus can be used to discriminate between the melatonin receptor subtypes.
Technical Data
| M. Wt | 275.31 |
| Formula | C14H17N3O3 |
| Storage | Store at RT |
| Purity | ≥97% (HPLC) |
| CAS Number | 190277-13-5 |
| PubChem ID | 4284525 |
| InChI Key | MPZVHKLZCUEJFO-UHFFFAOYSA-N |
| Smiles | COC(=O)NC1=CC=C2NC=C(CCNC(C)=O)C2=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in ethanol |
Preparing Stock Solutions
The following data is based on the product molecular weight 275.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.63 mL | 18.16 mL | 36.32 mL |
| 5 mM | 0.73 mL | 3.63 mL | 7.26 mL |
| 10 mM | 0.36 mL | 1.82 mL | 3.63 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.73 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Dubocovich (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50 PMID: 7762083
Lucchelli et al (1997) Investigation into the contractile response of melatonin in the guinea-pig isolated proximal colon: the role of 5-HT4 and melatonin receptors. Br.J.Pharmacol. 121 1775 PMID: 9283717
Keywords: GR 135531, supplier, High, affinity, melatonin, MT3, ligands, Receptors, GR135531, 5MCANAT, 5-MCA-NAT, Melatonin, (MT), Receptors, Melatonin, (MT), Receptors, Tocris Bioscience
