Biological Activity
Adenosine A1 receptor agonist (Ki = 3.1 nM). Anticonvulsive in mice following systemic administration in vivo.
Licensing Information
Sold for research purposes under agreement from GlaxoSmithKline
Technical Data
| M. Wt | 351.36 |
| Formula | C15H21N5O5 |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 124555-18-6 |
| PubChem ID | 9884817 |
| InChI Key | GYWXTRVEUURNEW-TVDBPQCTSA-N |
| Smiles | O[C@@H](CCC4)[C@H]4NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.57 | 50 | |
| ethanol | 3.51 | 10 | |
| water | 35.14 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 351.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.85 mL | 14.23 mL | 28.46 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.69 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.85 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Gurden et al (1993) Functional characterization of three adenosine receptor types. Br.J.Pharmacol. 109 693 PMID: 8358566
Knutsen et al (1999) N-Substituted adenosines as novel neuroprotective A1 agonists with diminished hypotensive effects. J.Med.Chem. 42 3463 PMID: 10479279
Merkel et al (1995) Cardiovascular and antilipolytic effects of the adenosine agonist GR 79236. Pharmacology 51 224 PMID: 8577816
Keywords: GR 79236, supplier, A1, agonists, Receptors, adenosines, GR79236, GlaxoSmithKline, GSK, Adenosine, A1, Receptors, Adenosine, A1, Receptors, Tocris Bioscience
