Biological Activity
Highly potent and selective κ-opioid agonist (IC50 = 0.04 nM) that may be selective for the putative κ2 receptor. Anti-nociceptive and neuroprotective in vivo.
Compound Libraries
GR 89696 fumarate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 530.4 |
| Formula | C19H25Cl2N3O3.C4H4O4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 126766-32-3 |
| PubChem ID | 6442840 |
| InChI Key | ABTNETSDXZBJTE-WLHGVMLRSA-N |
| Smiles | [H]OC(=O)C=CC(=O)O[H].COC(=O)N1CCN(C(CN2CCCC2)C1)C(=O)CC1=CC=C(Cl)C(Cl)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 53.04 | 100 | |
| water | 13.26 | 25mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 530.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.89 mL | 9.43 mL | 18.85 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.77 mL |
| 10 mM | 0.19 mL | 0.94 mL | 1.89 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Birch et al (1991) Neuroprotective actions of GR89696, a highly potent and selective κ-opioid receptor agonist. Br.J.Pharmacol. 103 1819 PMID: 1657267
Butelman et al (2001) GR89,696: a potent κ-opioid agonist with subtype selectivity in rhesus monkeys. J.Pharmacol.Exp.Ther. 298 1049 PMID: 11504802
Naylor et al (1993) A potent new class of κ-receptor agonist: 4-substituted 1-(arylacetyl)-2-[(dialkylamino)methyl]piperazines. J.Med.Chem. 36 2075 PMID: 8393489
Keywords: GR 89696 fumarate, supplier, Subtype-selective, κ-opioid, kappa-opioid, agonists, KOP, Receptors, OP2, GR89696, fumarate, Kappa, Opioid, Receptors, Kappa, Opioid, Receptors, Tocris Bioscience
