![Tocris/[Ac-Tyr1，D-Phe2]GRF 1-29，酰胺（人体）/1172/500U/500微克](https://www.ebiomall.cn/images/201712/1512521756115821138.jpg)
Biological Activity
VIP receptor antagonist; inhibits [125I]iodo-VIP binding and selectively inhibits VIP- and GRF-induced effects on adenylyl cyclase.
Technical Data
| M. Wt | 3475 |
| Formula | C157H252N44O43S |
| Sequence |
YFDAIFTNSYRKVLGQLSARKLLQDIMSR (Modifications: Tyr-1 = N-terminal Ac, Phe-2 = D-Phe, Arg-29 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 93965-89-0 |
| PubChem ID | 56841984 |
| InChI Key | ZADZHIQNEPVWIV-QSAFYHFUSA-N |
| Smiles | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(C)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 2 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 3475. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.29 mL | 1.44 mL | 2.88 mL |
| 5 mM | 0.06 mL | 0.29 mL | 0.58 mL |
| 10 mM | 0.03 mL | 0.14 mL | 0.29 mL |
| 50 mM | 0.01 mL | 0.03 mL | 0.06 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Nowak et al (1994) Evidence that endogenous vasoactive intestinal peptide (VIP) is involved in the regulation of rat pituitary-adrenocortical function: in vivo studies with a VIP antagonist. Neuropeptides 27 297 PMID: 7862261
Waelbroeck et al (1985) Interaction of growth hormone-releasing factor (GRF) and 14 GRF analogs with vasoactive intestinal peptide (VIP) receptors of rat pancreas. Discovery of (N-Ac-Tyr1,D-Phe2)-GRF(1-29)-NH2 as a VIP antagonist. Endocrinology 116 2643 PMID: 2859987
Keywords: [Ac-Tyr1,D-Phe2]GRF 1-29, amide (human), supplier, VIP, antagonist, Vasoactive, Intestinal, Peptide, Receptors, VPAC, [Ac-Tyr1D-Phe2]GRF1-29, amide, (human), VIP, Receptors, VIP, Receptors, Tocris Bioscience
