BiologicalActivity
PotentandselectiveFFA4(GPR120)agonist(pEC50valuesare6.3,6.2and6.1atthehuman,mouseandratreceptor,respectively).Exhibits≥100-foldselectivityagainstapanelof61targetsincludingFFA1,FFA2andFFA3.Enhancesglucose-stimulatedinsulinsecretioninMIN6cells.InducesintracellularcalciumaccumulationinU2OScells;thisactivityisinhibitedbyAH7614(Cat.No.5256).
LicensingInformation
SoldforresearchpurposesunderagreementfromGlaxoSmithKline
CompoundLibraries
GSK137647isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 305.39 |
| Formula | C16H19NO3S |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 349085-82-1 |
| PubChemID | 743974 |
| InChIKey | FQUAFMNPXPXOJE-UHFFFAOYSA-N |
| Smiles | CC1=CC(C)=CC(C)=C1NS(C2=CC=C(OC)C=C2)(=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.54 | 100 | |
| ethanol | 15.27 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight305.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.27mL | 16.37mL | 32.75mL |
| 5mM | 0.65mL | 3.27mL | 6.55mL |
| 10mM | 0.33mL | 1.64mL | 3.27mL |
| 50mM | 0.07mL | 0.33mL | 0.65mL |
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ProductDatasheets
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