Tocris/GSK 2194069/5303/50/50 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/GSK 2194069/5303/50/50 mg

Tocris/GSK 2194069/5303/50/50 mg

商品编号： 5303/50

品牌： Tocris Bioscience

市场价： ¥19300.00

美元价： 11580.00

产地：美国(厂家直采)

公司：

产品分类：其它酶

公司分类： Other_enzymes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

Description:Potenthumanfattyacidsynthase(hFASN)inhibitor

ChemicalName:4-[4-(5-Benzofuranyl)phenyl]-5-[[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potenthumanfattyacidsynthase(hFASN)inhibitor(IC₅₀=7.7nM);inhibitshFASβ-ketoacylreductaseactivity.InhibitslipidsynthesisandattenuatesproliferationofA549non-small-celllungcancercells(EC₅₀=15nM)invitro.

LicensingInformation

SoldforresearchpurposesunderagreementfromGlaxoSmithKline

CompoundLibraries

GSK2194069isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	428.48
Formula	C₂₅H₂₄N₄O₃
Storage	Storeat+4°C
Purity	≥99%(HPLC)
CASNumber	1332331-08-4
PubChemID	67376285
InChIKey	AQTPWCUIYUOEMG-INIZCTEOSA-N
Smiles	O=C1NN=C(C[C@@H]2CCN(C(C3CC3)=O)C2)N1C4=CC=C(C5=CC=C(OC=C6)C6=C5)C=C4

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	42.85	100
	ethanol	8.57	20

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight428.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.33mL	11.67mL	23.34mL
5mM	0.47mL	2.33mL	4.67mL
10mM	0.23mL	1.17mL	2.33mL
50mM	0.05mL	0.23mL	0.47mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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