BiologicalActivity
SelectiveBAZ2AandBAZ2Binhibitor(IC50valuesare0.40and0.43μM,respectively).SelectiveforBAZ2A/BoverTAF1LandBRD9.Cellpermeableandorallyavailable.
LicensingInformation
ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheGSK2801probesummaryontheSGCwebsite.
ExternalPortalInformation
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofGSK2801isreviewedonthechemicalprobeswebsite.
TechnicalData
| M.Wt | 371.45 |
| Formula | C20H21NO4S |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1619994-68-1 |
| PubChemID | 73010930 |
| InChIKey | KHWCPNJRJCNVRI-UHFFFAOYSA-N |
| Smiles | CCCOC1=CC2=C(C3=C(S(C)(=O)=O)C=CC=C3)C=C(C(C)=O)N2C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.57 | 50 | |
| ethanol | 3.71 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight371.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.69mL | 13.46mL | 26.92mL |
| 5mM | 0.54mL | 2.69mL | 5.38mL |
| 10mM | 0.27mL | 1.35mL | 2.69mL |
| 50mM | 0.05mL | 0.27mL | 0.54mL |
MolarityCalculator
ReconstitutionCalculator
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ProductDatasheets
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