Biological Activity
Selective Rev-Erbα agonist (EC50 = 250 nM). Enhances recruitment of nuclear receptor co-repressor (NCoR) peptide to Rev-Erbα; causes acute suppression of Bmal1 gene transcription. Induces phase shifts in the circadian clock.
Technical Data
| M. Wt | 396.89 |
| Formula | C18H21ClN2O4S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1216744-19-2 |
| PubChem ID | 50905018 |
| InChI Key | WYSLOKHVFKLWOU-UHFFFAOYSA-N |
| Smiles | CC(C)(C)OC(CN(CC2=CC=C(Cl)C=C2)CC1=CC=C([N+]([O-])=O)S1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.92 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 396.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.52 mL | 12.6 mL | 25.2 mL |
| 5 mM | 0.5 mL | 2.52 mL | 5.04 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.52 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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References
References are publications that support the products' biological activity.
Meng et al (2008) Ligand modulation of REV-ERBα function resets the peripheral circadian clock in a phasic manner. J.Cell Science 121 3629 PMID:
Kojetin et al (2011) Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem.Biol. 6 131 PMID: 21043485
Keywords: GSK 4112, supplier, GSK4112, REV-ERBA, REV-ERBα, REV-ERBalpha, agonists, circadian, rhythms, SR6452, SR, 6452, Rev-Erb, Receptors, Rev-Erb, Receptors, Tocris Bioscience
