BiologicalActivity
Serum-andglucocorticoid-regulatedkinase1(SGK1)inhibitor(IC50valuesare62and103nMforSGK1andSGK2respectively).Displays>30-foldselectivityoverAktandotherrelatedkinases.Inhibitsandrogen-stimulatedgrowthofLNCaPcells,ahumanprostatecarcinomacellline(IC50~1μM).
LicensingInformation
SoldwiththepermissionofGlaxoSmithKline
CompoundLibraries
GSK650394isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 382.45 |
| Formula | C25H22N2O2 |
| Storage | StoreatRT |
| Purity | ≥97%(HPLC) |
| CASNumber | 890842-28-1 |
| PubChemID | 25022668 |
| InChIKey | WVSBGSNVCDAMCF-UHFFFAOYSA-N |
| Smiles | O=C(C(C(C5CCCC5)=C4)=CC=C4C2=CNC1=NC=C(C3=CC=CC=C3)C=C12)O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.24 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight382.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.61mL | 13.07mL | 26.15mL |
| 5mM | 0.52mL | 2.61mL | 5.23mL |
| 10mM | 0.26mL | 1.31mL | 2.61mL |
| 50mM | 0.05mL | 0.26mL | 0.52mL |
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ProductDatasheets
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