Biological Activity
Selective dopamine D3 receptor antagonist and D2 partial agonist (pEC50 values are <5.5 and 8.3 respectively). Selective against the D4 receptor in both agonist and antagonist assays. Brain penetrant.
Technical Data
| M. Wt | 295.81 |
| Formula | C15H21N3O.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1257326-24-1 |
| PubChem ID | 57347570 |
| InChI Key | BYJUVPWUMBVSTK-UHFFFAOYSA-N |
| Smiles | O=C1N(CC3CCCCN3)CCN1C2=CC=CC=C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.58 | 100 | |
| water | 29.58 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 295.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.38 mL | 16.9 mL | 33.81 mL |
| 5 mM | 0.68 mL | 3.38 mL | 6.76 mL |
| 10 mM | 0.34 mL | 1.69 mL | 3.38 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Holmes et al (2010) The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure. Bioorg.Med.Chem.Lett. 20 2013 PMID: 20153647
Keywords: GSK 789472 hydrochloride, supplier, GSK789472, hydrochloride, dopamine, receptors, dopaminergic, D2, partial, agonists, D3, antagonists, D3, Receptors, D2, Receptors, D3, Receptors, Tocris Bioscience
