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主营:主营:分子类,蛋白类,抗体类,生化类试剂
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当前位置: 首页 > 产品中心 > Other_enzymes > Tocris/GSK J1/4593/50/50毫克
商品详细Tocris/GSK J1/4593/50/50毫克
Tocris/GSK J1/4593/50/50毫克
Tocris/GSK J1/4593/50/50毫克
商品编号: 4593/50
品牌: Tocris Bioscience
市场价: ¥16500.00
美元价: 9900.00
产地: 美国(厂家直采)
公司:
产品分类: 其它酶
公司分类: Other_enzymes
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description:PotentJMJD3/UTXinhibitor
ChemicalName:N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentinhibitoroftheH3K27histonedemethylasesJMJD3(KDM6B)andUTX(KDM6A)(IC50valuesare28and53nMrespectively).AlsoinhibitsKDM5B,KDM5CandKDM5A(IC50valuesare170,550and6,800nMrespectively).Exhibitsnoactivityagainstapanelofotherhistonedemethylases(IC50>20μM),anddisplaysnosignificantinhibitoryactivityagainst100proteinkinasesataconcentrationof30μM.Ethylesterderivativealsoavailable.

LicensingInformation

ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheGSKJ1probesummaryontheSGCwebsite.

CompoundLibraries

GSKJ1isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt389.45
FormulaC22H23N5O2
StorageDesiccateatRT
Purity≥99%(HPLC)
CASNumber1373422-53-7
PubChemID56963315
InChIKeyAVZCPICCWKMZDT-UHFFFAOYSA-N
SmilesO=C(CCNC1=NC(C2=CC=CC=N2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1)O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO38.94100
ethanol38.94100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight389.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.57mL12.84mL25.68mL
5mM0.51mL2.57mL5.14mL
10mM0.26mL1.28mL2.57mL
50mM0.05mL0.26mL0.51mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet