BiologicalActivity
InactivecontrolofGSKJ1(CatNo.4593)(IC50>100μMforinhibitionofJMJD3/UTX).Cellpermeableesterderivative,GSKJ5(Cat.No.4689),alsoavailable.
LicensingInformation
ThiscompoundissuppliedinconjunctionwiththeStructuralGenomicsConsortium.ForfurtherdetailsofGSKJ2,aninactiveisomerofGSKJ1,pleasevisittheGSKJ1probesummaryontheSGCwebsite.
CompoundLibraries
GSKJ2isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 389.45 |
| Formula | C22H23N5O2 |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 1394854-52-4 |
| PubChemID | 73010924 |
| InChIKey | LJIFOCRGDDQFJF-UHFFFAOYSA-N |
| Smiles | O=C(CCNC1=NC(C2=CC=CN=C2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1)O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 19.47 | 50 | |
| DMSO | 38.94 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight389.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.57mL | 12.84mL | 25.68mL |
| 5mM | 0.51mL | 2.57mL | 5.14mL |
| 10mM | 0.26mL | 1.28mL | 2.57mL |
| 50mM | 0.05mL | 0.26mL | 0.51mL |
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