BiologicalActivity
Histonelysinedemethylase(KDM)inhibitor;blocksdemethylationofhistoneH3K27.Attenuateslipopolysaccharide(LPS)-inducedproinflammatorycytokineproductioninprimaryhumanmacrophages(IC50=9μMfortheinhibitionofTNFαrelease).Cellpermeable.EthylesterderivativeofGSKJ1(Cat.No.4593).
LicensingInformation
ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.ForfurthercharacterizationdetailsofGSKJ4,acellpermeablederivativeofGSKJ1,pleasevisittheGSKJ1probesummaryontheSGCwebsite.
ExternalPortalInformation
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofGSKJ4isreviewedonthechemicalprobeswebsite.
CompoundLibraries
GSKJ4isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 417.5 |
| Formula | C24H27N5O2 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 1373423-53-0 |
| PubChemID | 71729975 |
| InChIKey | WBKCKEHGXNWYMO-UHFFFAOYSA-N |
| Smiles | O=C(CCNC1=NC(C2=CC=CC=N2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1)OCC |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.75 | 100 | |
| ethanol | 41.75 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight417.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.4mL | 11.98mL | 23.95mL |
| 5mM | 0.48mL | 2.4mL | 4.79mL |
| 10mM | 0.24mL | 1.2mL | 2.4mL |
| 50mM | 0.05mL | 0.24mL | 0.48mL |
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ProductDatasheets
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