BiologicalActivity
PotentandhighlyselectivePPARδagonist.EC50valuesare0.001,1.1and2μMfortransactivationofhumanPPARδ,-α,and-γreceptorsrespectively.Neuroprotectiveinratcerebellargranuleneuronalculturesafterbrief(12-hour)exposurebutexhibitsinherenttoxicityafterprolonged(48-hour)incubation.Increasesrateoffattyacidoxidationandprotectsagainstischemia/reperfusioninjuryinneonatalandadultcardiomyocytes.
LicensingInformation
SoldforresearchpurposesunderagreementfromGlaxoSmithKline
CompoundLibraries
GW0742isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 471.49 |
| Formula | C21H17F4NO3S2 |
| Storage | Desiccateat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 317318-84-6 |
| PubChemID | 9934458 |
| InChIKey | HWVNEWGKWRGSRK-UHFFFAOYSA-N |
| Smiles | CC1=C(CSC2=CC(C)=C(OCC(O)=O)C=C2)SC(=N1)C1=CC(F)=C(C=C1)C(F)(F)F |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.5 | 100 | |
| ethanol | 24.23 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight471.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.12mL | 10.6mL | 21.21mL |
| 5mM | 0.42mL | 2.12mL | 4.24mL |
| 10mM | 0.21mL | 1.06mL | 2.12mL |
| 50mM | 0.04mL | 0.21mL | 0.42mL |
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ProductDatasheets
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