BiologicalActivity
PotentandselectiveagonistforthefreefattyacidreceptorFFA1(GPR40)(pEC50valuesare7.32,<4.3and<4.3forFFA1,FFA2andFFA3receptorsrespectively).InactiveagainstarangeofotherGPCRs,kinases,proteases,integrinsandPPARs.Potentiatesglucose-stimulatedinsulinsecretioninMIN6cells(pEC50=6.14).
LicensingInformation
SoldwiththepermissionofGlaxoSmithKline
CompoundLibraries
GW9508isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 347.41 |
| Formula | C22H21NO3 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 885101-89-3 |
| PubChemID | 11595431 |
| InChIKey | DGENZVKCTGIDRZ-UHFFFAOYSA-N |
| Smiles | OC(=O)CCC1=CC=C(NCC2=CC=CC(OC3=CC=CC=C3)=C2)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.74 | 100 | |
| ethanol | 34.74 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight347.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.88mL | 14.39mL | 28.78mL |
| 5mM | 0.58mL | 2.88mL | 5.76mL |
| 10mM | 0.29mL | 1.44mL | 2.88mL |
| 50mM | 0.06mL | 0.29mL | 0.58mL |
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ProductDatasheets
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