Biological Activity
Calcium-sensing receptor (CaSR) agonist; induces NLRP3 inflammasome activation in bone marrow-derived macrophages. Blocks stretch-activated calcium channels; inhibits increase in intracellular calcium ion concentration in hypotonic-stimulated pulmonary artery smooth muscle cells. Has been demonstrated to block TRPML channel currents and other TRP channels.
Technical Data
| M. Wt | 263.61 |
| Formula | GdCl3 |
| Storage | Desiccate at RT |
| CAS Number | 10138-52-0 |
| PubChem ID | 61486 |
| InChI Key | MEANOSLIBWSCIT-UHFFFAOYSA-K |
| Smiles | Cl[Gd](Cl)Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 26.36 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 263.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.79 mL | 18.97 mL | 37.93 mL |
| 5 mM | 0.76 mL | 3.79 mL | 7.59 mL |
| 10 mM | 0.38 mL | 1.9 mL | 3.79 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.76 mL |
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References
References are publications that support the products' biological activity.
Nishitani et al (2011) Calcium signaling in live cells on elastic gels under mechanical vibration at subcellular levels. PLoS One. 6 e26181 PMID: 22053183
Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123 PMID: 23143333
Del Favero et al (2012) The stretch-activated channel blocker Gd3+ reduces palytoxin toxicity in primary cultures of skeletal muscle cells. Chem.Res.Toxicol. 25 1912 PMID: 22900474
Nagata et al (2008) The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration. Proc.Natl.Acad.Sci.U.S.A. 105 353 PMID: 18162548
Keywords: Gadolinium chloride, supplier, CaSR, calcium, sensing, receptors, agonists, stretch, activated, calcium, channels, blockers, TRP, TRPML, Other, Calcium, Channels, Calcium-Sensing, Receptor, TRPML, Other, Calcium, Channels, Tocris Bioscience
