Biological Activity
Non-selective galanin receptor agonist (Ki values are 0.98, 1.48 and 1.47 nM for GAL1, GAL2 and GAL3 respectively). Anticonvulsant; prevents the occurrence of full kindled seizures in rats.
Technical Data
| M. Wt | 3164.48 |
| Formula | C141H211N43O41 |
| Sequence |
GWTLNSAGYLLGPHAIDNHRSFSDKHGLT (Modifications: Thr-29 = C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 114547-31-8 |
| PubChem ID | 16201477 |
| InChI Key | JHQDYHHNJBOXKP-UPNHMZDKSA-N |
| Smiles | [H]NCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC=N1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 3164.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.32 mL | 1.58 mL | 3.16 mL |
| 5 mM | 0.06 mL | 0.32 mL | 0.63 mL |
| 10 mM | 0.03 mL | 0.16 mL | 0.32 mL |
| 50 mM | 0.01 mL | 0.03 mL | 0.06 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Wang et al (1997) Cloning and expression characterization of a novel galanin receptor. J.Biol.Chem. 272 51 PMID: 8995226
Mazarati et al (2006) Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: the effects of subtype-selective agonists and the role of G-protein-mediated signaling. J.Pharmacol.Exp.Ther. 318 700 PMID: 16699066
Branchek et al (2000) Galanin receptor subtypes. TiPS. 21 109 PMID:
Keywords: Galanin (1-29) (rat, mouse), supplier, Non-Selective, galanin, receptors, agonists, GAL, GalR, Galanin, Receptors, Galanin, Receptors, Tocris Bioscience
