Biological Activity
N-terminal galanin fragment. In contrast to the full length (1-29) peptide, mediates central cardiovascular effects, perhaps by binding to a novel receptor type.
Technical Data
| M. Wt | 1556.74 |
| Formula | C72H105N19O20 |
| Sequence | GWTLNSAGYLLGPHA |
| Storage | Desiccate at -20°C |
| CAS Number | 112747-70-3 |
| PubChem ID | 16131409 |
| InChI Key | LOXLDVDBPRBBLT-GDRYISODSA-N |
| Smiles | [H]NCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1556.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.64 mL | 3.21 mL | 6.42 mL |
| 5 mM | 0.13 mL | 0.64 mL | 1.28 mL |
| 10 mM | 0.06 mL | 0.32 mL | 0.64 mL |
| 50 mM | 0.01 mL | 0.06 mL | 0.13 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Amiranoff et al (1989) Structural requirements for galanin action in the pancreatic β cell line rin m 5F. Eur.J.Pharmacol. 163 205 PMID: 2472967
Narvaez et al (2000) The galanin receptor antagonist M40 blocks the central cardiovascular actions of the galanin N-terminal fragment (1-15). Eur.J.Pharmacol. 399 197 PMID: 10884520
Xu et al (1999) Electrophysiological evidence for a hyperpolarizing, galanin (1-15)-selective receptor on hippocampal CA3 pyramidal neurons. Proc.Natl.Acad.Sci.USA 96 14583 PMID: 10588748
Keywords: Galanin (1-15) (porcine, rat), supplier, Galanin, receptor, agonists, peptide, GAL, GalR, Galanin, Receptors, Galanin, Receptors, Tocris Bioscience
