Biological Activity
Novel non-peptide galanin GAL1 and GAL2 receptor agonist (Ki values are 11.7 and 34.1 μM respectively). Stimulates insulin release in isolated pancreatic islets from normal and diabetic rats. Systemically active in vivo; displays anticonvulsant activity following i.p. administration in mice. Central and peripheral administration also transiently inhibits food intake in rats and mice.
Technical Data
| M. Wt | 678.83 |
| Formula | C40H46N4O6 |
| Sequence |
AK (Modifications: Ala-1 = Fmoc-β-cyclohexyl-Ala, Lys-2 = Lys-(4-methyl-2-oxo-2H-1-benzopyran) |
| Storage | Desiccate at -20°C |
| CAS Number | 475115-35-6 |
| PubChem ID | 5311268 |
| InChI Key | IKNOZZKXIDSTRN-PXLJZGITSA-N |
| Smiles | CC1=CC(=O)OC2=C1C=CC(NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC1CCCCC1)NC(=O)OCC1C3=CC=CC=C3C3=C1C=CC=C3)=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 67.88 mg/ml in DMSO and to 16.97 mg/ml in ethanol with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 678.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.47 mL | 7.37 mL | 14.73 mL |
| 5 mM | 0.29 mL | 1.47 mL | 2.95 mL |
| 10 mM | 0.15 mL | 0.74 mL | 1.47 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.29 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Abramov et al (2004) Regulation of feeding by galnon. Neuropeptides 38 55 PMID: 15003717
Saar et al (2002) Anticonvulsant activity of a nonpeptide galanin receptor agonist Proc.Natl.Acad.Sci.USA 99 7136 PMID: 12011470
Lu et al (2005) A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proc.Natl.Acad.Sci. 102 874 PMID: 15647369
Quynh et al (2005) Effects of galnon, a non-peptide galanin-receptor agonist, on insulin release from rat pancreatic islets. Biochem.Biophys.Res.Comm. 328 213 PMID: 15670772
Keywords: Galnon, supplier, Selective, non-peptide, GAL1, GalR1, agonists, Receptors, Galanin, Galanin, Receptors, Galanin, Receptors, Tocris Bioscience
