Biological Activity
Potent positive allosteric modulator of GABAA receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABAA receptors (EC50 values are 94, 122 and 213 nM for α2β1γ2L, α3β1γ2L and α1β1γ2L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.
Technical Data
| M. Wt | 332.53 |
| Formula | C22H36O2 |
| Storage | Store at +4°C |
| CAS Number | 38398-32-2 |
| PubChem ID | 6918305 |
| InChI Key | PGTVWKLGGCQMBR-FLBATMFCSA-N |
| Smiles | O[C@]1(C)CC[C@@]2(C)[C@](CC[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@H]4[C@](C)=O)([H])C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.33 | 10mM with gentle warming | |
| ethanol | 6.65 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 332.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.01 mL | 15.04 mL | 30.07 mL |
| 5 mM | 0.6 mL | 3.01 mL | 6.01 mL |
| 10 mM | 0.3 mL | 1.5 mL | 3.01 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.6 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Carter et al (1997) Characterization of the anticonvulsive properties of ganaxolone (CCD 1044; 3α-hydroxy-3β-methyl-5α-pregnan-20-one), a selective, high affinity, steroid modulator of the γ-aminobutyric acidA receptor. J.Pharmacol.Exp.Ther. 280 1284 PMID: 9067315
Lyden et al (2000) Effect of ganaxolone in a rodent model of cerebral hematoma. Stroke 31 169 PMID: 10625734
Ungard et al (2000) Modification of behavioral effects of drugs in mice by neuroactive steroids. Psychopharmacology 148 336 PMID: 10928304
Keywords: Ganaxolone, supplier, Potent, positive, allosteric, modulators, GABAA, receptors, Receptors, CCD1042, CCD, 1042, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience
