Tocris/ME 0328/5054/50/50毫克-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/ME 0328/5054/50/50毫克

Tocris/ME 0328/5054/50/50毫克

商品编号： 5054/50

品牌： Tocris Bioscience

市场价： ¥15300.00

美元价： 9180.00

产地：美国(厂家直采)

公司：

产品分类： DNA聚合酶

公司分类： DNA_polymerase

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:SelectivePARP-3inhibitor

ChemicalName:3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

InhibitorofPARP-3(IC₅₀=0.89μM).DisplaysselectivityforPARP-3overPARP-1,PARP-2andotherARDTenzymes(IC₅₀valuesare6.3,10.8and>30μMrespectively).EnhancesCRISPR-Cas9-mediatedHER2mutationfrequency,resultinginincreasedreductioninproliferationofHER2-positivebreastcancercells.Cellpermeable.

CompoundLibraries

ME0328isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	321.37
Formula	C₁₉H₁₉N₃O₂
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	1445251-22-8
PubChemID	71571526
InChIKey	QIHBWVVVRYYYRO-ZDUSSCGKSA-N
Smiles	O=C2NC(CCC(N[C@@H](C)C3=CC=CC=C3)=O)=NC1=CC=CC=C12

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	32.14	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight321.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	3.11mL	15.56mL	31.12mL
5mM	0.62mL	3.11mL	6.22mL
10mM	0.31mL	1.56mL	3.11mL
50mM	0.06mL	0.31mL	0.62mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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BiologicalActivity

CompoundLibraries

TechnicalData

SolubilityData

PreparingStockSolutions

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ProductDatasheets