Biological Activity
Inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity (IC50 values are 5 and 7 μM, respectively). Promotes expansion of human HSCs ex vivo. Causes reversal of EMT and inhibits β-catenin in breast cancer cell lines MDA-MB-231 and BT-549.
Technical Data
| M. Wt | 602.8 |
| Formula | C38H50O6 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 78824-30-3 |
| PubChem ID | 22245705 |
| InChI Key | KCODNOOPOPTZMO-UHFFFAOYSA-N |
| Smiles | O=C1C(C(C2=CC(O)=C(O)C=C2)=O)=C(O)[C@](C[C@H](C/C=C(C)/C)C(C)=C)([C@@]3=O)C[C@@H](C/C=C(C)/C)C(C)(C)[C@]31C/C=C(C)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 60.28 | 100 | |
| ethanol | 60.28 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 602.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.66 mL | 8.29 mL | 16.59 mL |
| 5 mM | 0.33 mL | 1.66 mL | 3.32 mL |
| 10 mM | 0.17 mL | 0.83 mL | 1.66 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.33 mL |
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References
References are publications that support the products' biological activity.
Ahmad et al (2012) Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading to anticancer activity against breast cancer cells. Mol.Cancer.Ther. 11 2193 PMID: 22821148
Balasubramanyam et al (2004) Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. J.Biol.Chem. 279 33716 PMID: 15155757
Nishino et al (2011) Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent inhibitor of histone acetyltransferase. PLoS One 6 e24298 PMID: 21931675
Keywords: Garcinol, supplier, inhibitors, inhibits, histone, acetyltransferase, HAT, PCAF, p300, HSCs, EMT, MET, β-catenin, breast, cancer, hematopoietic, stem, cells, epithelial, to, mesenchymal, transition, Histone, Acetyltransferases, Stem, Cell, Proliferation, Histone, Acetyltransferases, Tocris Bioscience
