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当前位置: 首页 > 产品中心 > Signal_pathway > Tocris/Gavestinel/2348/10/10 mg
商品详细Tocris/Gavestinel/2348/10/10 mg
Tocris/Gavestinel/2348/10/10 mg
Tocris/Gavestinel/2348/10/10 mg
商品编号: 2348/10
品牌: Tocris Bioscience
市场价: ¥3380.00
美元价: 2028.00
产地: 美国(厂家直采)
公司:
产品分类: 信号通路
公司分类: Signal_pathway
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description:PotentandselectiveglycinesiteantagoNIST;orallyavailableandactiveinvivo
AlternativeNames:GV150526A
ChemicalName:4,6-Dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylicacidsodiumsalt
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Highlypotentandselectivenon-competitiveantagonistactingatthestrychnine-insensitiveglycinebindingsiteoftheNMDAreceptor-channelcomplex(Kd=0.8nM).Displays>1000-foldselectivityoverNMDA,AMPAandkainatebindingsites.Orallybioavailableandactiveinvivo.

LicensingInformation

SoldwiththepermissionofGlaxoSmithKline

CompoundLibraries

GavestinelisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt397.19
FormulaC18H11Cl2N2O3Na
StorageDesiccateatRT
Purity≥98%(HPLC)
CASNumber153436-38-5
PubChemID16759177
InChIKeyGRSDSTMFQHAESM-UHDJGPCESA-M
Smiles[Na+].[O-]C(=O)C1=C(C=CC(=O)NC2=CC=CC=C2)C2=C(N1)C=C(Cl)C=C2Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO15.8940

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight397.19.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.52mL12.59mL25.18mL
5mM0.5mL2.52mL5.04mL
10mM0.25mL1.26mL2.52mL
50mM0.05mL0.25mL0.5mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet