BiologicalActivity
NaturallyoccurringHsp90inhibitor.InducesHsp90-dependentclientproteindegradationanddisplaysantiproliferativeactivityinvitro(IC50valuesare3.22,8.84and16.8μMinSKBr3,MCF-7andCaCo-2cancercelllinesrespectively).Decreasesovariancancercellproliferationinvitroandmayenhancecisplatin-inducedreductioninproliferation(CAT.No3387).AlsoexhibitsantimalarialactivityagainstP.falciparum(IC50valuesare0.14and3.1μMinparasitedevelopmentand[3H]-hypoxanthineuptakeassaysrespectively).
TechnicalData
| M.Wt | 482.57 |
| Formula | C28H34O7 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 2753-30-2 |
| PubChemID | 12004512 |
| InChIKey | YJXDGWUNRYLINJ-BHAPSIHVSA-N |
| Smiles | O=C4[C@@H]6[C@]3(O6)[C@]2(C)[C@H](OC(C)=O)C[C@@]1([H])C(C)(C)C(C=C[C@@](C)1[C@]([H])2CC[C@](C)3[C@H]([C@]5=COC=C5)O4)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.26 | 100 | |
| ethanol | 4.83 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight482.57.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.07mL | 10.36mL | 20.72mL |
| 5mM | 0.41mL | 2.07mL | 4.14mL |
| 10mM | 0.21mL | 1.04mL | 2.07mL |
| 50mM | 0.04mL | 0.21mL | 0.41mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
本网站将在规定时间内给予删除等相关处理。
