BiologicalActivity
DeoxycytidineanalogthatinhibitsDNAsynthesis.MetabolizedtoformgemcitABInetriphosphate(dFdCTP)andgemcitabinediphosphate(dFdCDP).dFdCTDinhibitsribonucleotidereductasecausingareductionincellularnucleotides.dFdCTPisincorporatedinDNAresultinginDNAstrandtermination.Displaysantitumoractivityinvitroandinvivo.
CompoundLibraries
GemcitabinehydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 299.66 |
| Formula | C9H11F2N3O4.HCl |
| Storage | Desiccateat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 122111-03-9 |
| PubChemID | 69101485 |
| InChIKey | OKKDEIYWILRZIA-OSZBKLCCSA-N |
| Smiles | OC[C@@H]1[C@@H](O)C(F)(F)[C@H](N2C(N=C(N)C=C2)=O)O1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.99 | 20 | |
| water | 29.97 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight299.66.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.34mL | 16.69mL | 33.37mL |
| 5mM | 0.67mL | 3.34mL | 6.67mL |
| 10mM | 0.33mL | 1.67mL | 3.34mL |
| 50mM | 0.07mL | 0.33mL | 0.67mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
本网站将在规定时间内给予删除等相关处理。
