Biological Activity
An endogenous ligand for the ghrelin receptor (GHS-R1a), produced by alternative splicing of the rat ghrelin gene. Potently induces Ca2+ release in cells expressing ghrelin receptors (EC50 = 2.4 nM) and stimulates GH release in vivo.
Licensing Information
This peptide is distributed under license from Dr. Kangawa
Technical Data
| M. Wt | 3186.7 |
| Formula | C142H237N43O40 |
| Sequence |
GSSFLSPEHQKAQRKESKKPPAKLQPR (Modifications: Ser-3 = Ser(n-octanoyl)) |
| Storage | Desiccate at -20°C |
| CAS Number | 293735-04-3 |
| PubChem ID | 90479785 |
| InChI Key | GKDHXLGLEXRRSB-MVILVGDSSA-N |
| Smiles | [H]NCC(=O)N[C@@H](CO)C(=O)N[C@@H](COC(=O)CCCCCCC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 2 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 3186.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.31 mL | 1.57 mL | 3.14 mL |
| 5 mM | 0.06 mL | 0.31 mL | 0.63 mL |
| 10 mM | 0.03 mL | 0.16 mL | 0.31 mL |
| 50 mM | 0.01 mL | 0.03 mL | 0.06 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Hosoda et al (2000) Purification and characterization of rat des-Gln14-ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor. J.Biol.Chem. 275 21995 PMID: 10801861
Keywords: des-Gln14-Ghrelin (rat), supplier, Endogenous, ghrelin, receptor, ligands, GHS-R1a, Receptors, Growth, Hormone, Secretagog, Receptor, 1a, Ghrelin, Receptors, Ghrelin, Receptors, Tocris Bioscience
