Biological Activity
Potent Kir6 (KATP) channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac Kir6 channels with an IC50 of 6.8 nM.
Technical Data
| M. Wt | 490.62 |
| Formula | C24H34N4O5S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 93479-97-1 |
| PubChem ID | 3476 |
| InChI Key | WIGIZIANZCJQQY-UHFFFAOYSA-N |
| Smiles | O=C1C(CC)=C(C)CN1C(NCCC2=CC=C(S(NC(N[C@H]3CC[C@H](C)CC3)=O)(=O)=O)C=C2)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 12.27 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 490.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.04 mL | 10.19 mL | 20.38 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.08 mL |
| 10 mM | 0.2 mL | 1.02 mL | 2.04 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.41 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Lawrence et al (2002) Effect of metabolic inhibition on glimepiride block of native and cloned cardiac sacrolemmal KATP channels. Br.J.Pharmacol. 136 746 PMID: 12086984
Keywords: Glimepiride, supplier, KATP, channels, openers, Potassium, KIR, Inward, Rectifier, K+, Kir6, Amaryl, Glimperide, Inward, rectifier, Potassium, Channels, Inward, rectifier, Potassium, Channels, Tocris Bioscience
