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商品详细Tocris/Gliotoxin/2637/1/1 mg

Tocris/Gliotoxin/2637/1/1 mg

商品编号： 2637/1

品牌： Tocris Bioscience

市场价： ¥1900.00

美元价： 1140.00

产地：美国(厂家直采)

公司：

产品分类：蛋白酶类

公司分类： protease

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:Inhibitorof20Sproteasome;immunosuppressant

AlternativeNames:Aspergillin

ChemicalName:(3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dione

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Immunosuppressiveagent;blocksphagocytosis,cytokineproductionandproliferationofTandBcells.Non-competitivelyinhibitschymotrypsin-likeactivityof20Sproteasome;preventsdegradationofIκBα,anendogenousblockerofNF-κB.AlsoinhibitsfarnesyltransferaseandgeranylgeranyltransferaseI(IC₅₀valuesare80and17μMrespectively)anddisplaysantitumoractivityagainstbreastcancerinvivo.

TechnicalData

M.Wt	326.38
Formula	C₁₃H₁₄N₂O₄S₂
Storage	Desiccateat-20°C
CASNumber	67-99-2
PubChemID	6223
InChIKey	FIVPIPIDMRVLAY-RBJBARPLSA-N
Smiles	O=C([C@@]2(SS4)N(C([C@@]43CO)=O)[C@@H]1[C@@H](O)C=CC=C1C2)N3C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

Solubility	SolubleinDMSOandinethanol

Solubility

SolubleinDMSOandinethanol

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight326.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	3.06mL	15.32mL	30.64mL
5mM	0.61mL	3.06mL	6.13mL
10mM	0.31mL	1.53mL	3.06mL
50mM	0.06mL	0.31mL	0.61mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

TechnicalData

SolubilityData

PreparingStockSolutions

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