![Tocris/des-His1-[Glu9]-Glucagon (1-29) amide/2216/1/1 mg](https://www.ebiomall.cn/images/201712/1512521756115821138.jpg)
Biological Activity
Glucagon receptor antagonist (pA2 = 7.2 for inhibition of glucagon-induced adenylyl cyclase activation in rat liver membranes); displays no agonist activity. Enhances glucose-stimulated pancreatic insulin release in vitro. Blocks added glucagon-induced hyperglycemia in normal rabbits without affecting glycogenolysis in vivo. Also blocks endogenous glucagon-induced hyperglycemia in streptozocin diabetic rats.
Technical Data
| M. Wt | 3358.68 |
| Formula | C148H221N41O47S |
| Sequence |
SQGTFTSEYSKYLDSRRAQDFVQWLMNT (Modifications: Thr-28 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 110084-95-2 |
| PubChem ID | 16133829 |
| InChI Key | RVXSASLSNHDASC-OSWDIKPLSA-N |
| Smiles | [H]N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 3358.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.3 mL | 1.49 mL | 2.98 mL |
| 5 mM | 0.06 mL | 0.3 mL | 0.6 mL |
| 10 mM | 0.03 mL | 0.15 mL | 0.3 mL |
| 50 mM | 0.01 mL | 0.03 mL | 0.06 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Unson et al (1989) Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist. Peptides 10 1171 PMID: 2560175
Huypens et al (2000) Glucagon receptors on human islet cells contribute to glucose competence of insulin release. Diabetologia 43 1012 PMID: 10990079
Unson et al (1987) Synthetic peptide antagonists of glucagon. Proc.Natl.Acad.Sci.USA 84 4083 PMID:
Keywords: des-His1-[Glu9)-Glucagon (1-29) amide, supplier, Glucagon, receptor, antagonists, antagonist, receptors, Glucagon, Receptor, Glucagon, Receptor, Tocris Bioscience
