Biological Activity
One of the major inhibitory neurotransmitters in the mammalian CNS, predominantly active in the spinal cord and brain stem. Also acts as a modulator of excitatory amino acid transmission mediated by NMDA receptors. Also available as part of the NMDA Receptor - Glycine Site Tocriset™.
Technical Data
| M. Wt | 75.07 |
| Formula | C2H5NO2 |
| Storage | Store at RT |
| CAS Number | 56-40-6 |
| PubChem ID | 750 |
| InChI Key | DHMQDGOQFOQNFH-UHFFFAOYSA-N |
| Smiles | NCC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 75.07. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 13.32 mL | 66.6 mL | 133.21 mL |
| 5 mM | 2.66 mL | 13.32 mL | 26.64 mL |
| 10 mM | 1.33 mL | 6.66 mL | 13.32 mL |
| 50 mM | 0.27 mL | 1.33 mL | 2.66 mL |
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References
References are publications that support the products' biological activity.
Betz (1991) Glycine receptors: heterogeneous and widespread in the mammalian brain. Trends Neurosci. 14 458 PMID: 1722365
Kuhse et al (1995) The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex. Curr.Opin.Neurobiol. 5 318 PMID: 7850154
Ascher and Johnson (1989) The NMDA receptor, its channel and its modulation by glycine. The NMDA Receptor (2nd edition). Eds. G.L.Collingr 109 PMID:
Johnson and Ascher (1987) Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 325 529 PMID:
Keywords: Glycine, supplier, Endogenous, glycine, receptor, agonists, potentiator, co-transmitter, GlyR, Glycine, Receptors, Glutamate, NMDA, N-Methyl-D-Aspartate, iGluR, Ionotropic, NMDA, Receptors, Glycine, Receptors, NMDA, Receptors, Tocris Bioscience
