BiologicalActivity
BroadspectrumproteinkinaseC(PKC)inhibitor(IC50valuesare7,7,6,10,60and20000nMforPKCα,PKCβ,PKCγ,PKCδ,PKCζandPKCμrespectively).Displayscardioprotectiveproperties;reducespolymorphonuclearleukocyteadherenceandinfiltrationfollowingmyocardialischemia/reperfusioninjury.OptimizesnaïvehumanpluripotentstemcellgrowthandviABIlityfollowingnaïvecellderivationfromprimedESCsandiPSCsusingnaïvehumanstemcellmedium(NHSM).
TechnicalData
| M.Wt | 442.51 |
| Formula | C26H26N4O3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 133053-19-7 |
| PubChemID | 3499 |
| InChIKey | LLJJDLHGZUOMQP-UHFFFAOYSA-N |
| Smiles | O=C(N1)C(C2=CNC3=C2C=CC=C3)=C(C4=CN(CCCN(C)C)C5=C4C=C(OC)C=C5)C1=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.12 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight442.51.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.26mL | 11.3mL | 22.6mL |
| 5mM | 0.45mL | 2.26mL | 4.52mL |
| 10mM | 0.23mL | 1.13mL | 2.26mL |
| 50mM | 0.05mL | 0.23mL | 0.45mL |
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