Biological Activity
Potent, specific and reversible inhibitor of Golgi BFA resistance factor 1 (GBF1), an ArfGEF, that decreases Arf1 activation in vivo. Arrests secretion of soluble and membrane-associated proteins at the endoplasmic reticulum-Golgi intermediate compartment. Causes disassembly and dispersal of the Golgi and trans-Golgi network.
Compound Libraries
Golgicide A is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 284.3 |
| Formula | C17H14F2N2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1139889-93-2 |
| PubChem ID | 25113626 |
| InChI Key | NJZHEQOUHLZCOX-FTLRAWMYSA-N |
| Smiles | FC4=CC([C@]3([H])[C@]([H])2CC=C3)=C(C(F)=C4)NC2C1=CN=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 14.21 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 284.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.52 mL | 17.59 mL | 35.17 mL |
| 5 mM | 0.7 mL | 3.52 mL | 7.03 mL |
| 10 mM | 0.35 mL | 1.76 mL | 3.52 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.7 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Saenz et al (2008) Golgicide A reveals essential roles for GBF1 in Golgi assembly and function. Nature Chem.Biol. 5 157 PMID:
Keywords: Golgicide A, supplier, potent, specific, reversible, inhibitors, inhibits, Golgi, BFA, resistance, factors, 1, GBF1, ArfGEF, ADP, ribosylation, factor, guanine, nucleotide, exchange, GTPase, G, Proteins, (Small), Translocation,, Exocytosis, &, Endocytosis, GTPase, Tocris Bioscience
