Biological Activity
5-HT3 receptor antagonist that possesses potent antiemetic activity.
Technical Data
| M. Wt | 348.87 |
| Formula | C18H24N4O.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 107007-99-8 |
| PubChem ID | 65264 |
| InChI Key | QYZRTBKYBJRGJB-UHFFFAOYSA-N |
| Smiles | O=C(C3=NN(C)C4=C3C=CC=C4)NC1CC(N2C)CCCC2C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.49 | 10 | |
| water | 34.89 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 348.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.87 mL | 14.33 mL | 28.66 mL |
| 5 mM | 0.57 mL | 2.87 mL | 5.73 mL |
| 10 mM | 0.29 mL | 1.43 mL | 2.87 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Sanger and Nelson (1989) Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron). Eur.J.Pharmacol. 159 113 PMID: 2540014
Plosker and Goa (1991) Granisetron. A review of its pharmacological properties and therapeutic use as an antiemetic. Drugs 42 805 PMID: 1723376
Martin et al (1998) Anti-emetic effect of Ondansetron and Granisetron after exposure to mixed neutron and gamma irradiation. Rad.Res. 149 631 PMID:
Keywords: Granisetron hydrochloride, supplier, 5-HT3, antagonists, Serotonin, Receptors, BRL43694, BRL, 43694, 5-HT3, Receptors, 5-HT3, Receptors, Tocris Bioscience
