Biological Activity
Selective partial FFA4 (GPR120) agonist. Induces ERK and [Ca2+]i responses in cells expressing GPR120, but not those expressing GPR40.
Technical Data
| M. Wt | 372.5 |
| Formula | C23H32O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 80557-12-6 |
| PubChem ID | 9976563 |
| InChI Key | QPIZDZGIXDKCRC-JTCWOHKRSA-N |
| Smiles | OC1=C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)C(O)=C(C(O)=O)C(C)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.25 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 372.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.68 mL | 13.42 mL | 26.85 mL |
| 5 mM | 0.54 mL | 2.68 mL | 5.37 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.68 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Hara et al (2009) Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn Schmiedebergs Arch.Pharmacol. 380 247 PMID: 19471906
Sun et al (2010) Structure-activity relationships of GPR120 agonists based on a docking simulation. Mol.Pharmacol. 78 804 PMID: 20685848
Keywords: Grifolic acid, supplier, G, protein-coupled, receptors, GPR120, orphan, selective, partial, agonists, FFA4, free, fatty, acid, receptors, Free, Fatty, Acid, Receptors, Free, Fatty, Acid, Receptors, Tocris Bioscience
