Biological Activity
α2-adrenergic agonist and IGRS (imidazoline I2 binding site) selective ligand.
Technical Data
| M. Wt | 291.14 |
| Formula | C8H8Cl2N4.CH3CO2H |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 23256-50-0 |
| PubChem ID | 5702062 |
| InChI Key | MCSPBPXATWBACD-GAYQJXMFSA-N |
| Smiles | CC(O)=O.ClC1=C(/C=N/NC(N)=N)C(Cl)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 21.84 | 75 |
Preparing Stock Solutions
The following data is based on the product molecular weight 291.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.43 mL | 17.17 mL | 34.35 mL |
| 5 mM | 0.69 mL | 3.43 mL | 6.87 mL |
| 10 mM | 0.34 mL | 1.72 mL | 3.43 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.69 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Evans and Anderson (1995) Renal effects of infusion of rilmenidine and guanabenz in conscious dogs: contribution of peripheral and central nervous system α2-adrenoceptors. Br.J.Pharmacol. 116 1557 PMID: 8564219
Holmes et al (1983) Guanabenz. A review of its pharmacodynamic properties and therapeutic efficacy in hypertension. Drugs 26 212 PMID: 6352237
Michel and Insel (1989) Are there multiple imidazoline binding sites? Trends Pharmacol.Sci. 10 342 PMID: 2690423
Merck Index 12 4585 PMID:
Keywords: Guanabenz acetate, supplier, α2-adrenoceptor, alpha2-adrenoceptor, α2-Adrenergic, alpha2-Adrenergic, a2-adrenoceptor, a2-adrenergic, agonists, I2, selective, ligands, Adrenoceptors, Imidazoline, Adrenergic, Alpha-2, Receptors, I2, Receptors, Adrenergic, Alpha-2, Receptors, Tocris Bioscience
