Biological Activity
Selective α2A-adrenoceptor agonist (Kd = 31 nM). Displays 60-fold selectivity over α2B-adrenoceptors. Also available as part of the α2-Adrenoceptor Tocriset™.
Technical Data
| M. Wt | 282.56 |
| Formula | C9H9Cl2N3O.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 29110-48-3 |
| PubChem ID | 71401 |
| InChI Key | DGFYECXYGUIODH-UHFFFAOYSA-N |
| Smiles | Cl.NC(=N)NC(=O)CC1=C(Cl)C=CC=C1Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.26 | 100 | |
| water | 28.26 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 282.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.54 mL | 17.7 mL | 35.39 mL |
| 5 mM | 0.71 mL | 3.54 mL | 7.08 mL |
| 10 mM | 0.35 mL | 1.77 mL | 3.54 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.71 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Intengan and Smyth (1997) Alpha-2a/d adrenoceptor subtype stimulation by guanfacine increases osmolar clearance. J.Pharmacol.Exp.Ther. 281 48 PMID: 9103479
Uhlen and Wikberg (1991) Delineation of rat kidney α2A- and α2B-adrenoceptors with [3H]RX821002 radioligand binding: computer modelling reveals that guanfacine is an α2A -selective compound. Eur.J.Pharmacol. 202 235 PMID: 1666366
Merck Index 12 4590 PMID:
Keywords: Guanfacine hydrochloride, supplier, α2A-adrenoceptor, alpha2A-adrenoceptor, a2a-adrenoceptor, a2a-adrenergic, α2a-adrenergic, alpha2a-adrenergic, agonists, Receptors, Adrenergic, Alpha-2, Receptors, Adrenergic, Alpha-2, Receptors, Tocris Bioscience
