BiologicalActivity
Broadspectrumsteroidreceptorligand;mineralocorticoid,progesteroneandglucocorticoidreceptorantagoNIST(Kivaluesare37,224and252nMrespectively)andweakandrogenreceptoragonist(Ki=315nM).InducesapoptosisinprostatecancercellsandinhibitsangiogenesisviasuppressionoftheVEGF-VEGFR2-Aktsignalingpathway.ExhibitsantilipidemicactivityviaantagonismofthefarnesoidXreceptor(FXR)anddisplaysantiseptic,antirheumaticandanti-inflammatoryactivityinvivo.Moreactiveisomerofguggulsterone(Cat.No.2013).
TechnicalData
| M.Wt | 312.45 |
| Formula | C21H28O2 |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 39025-23-5 |
| PubChemID | 6450278 |
| InChIKey | WDXRGPWQVHZTQJ-OSJVMJFVSA-N |
| Smiles | O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@@]([H])2CC[C@@]/4(C)[C@]([H])3CC(C4=C/C)=O)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.25 | 20mMwithgentlewarming | |
| ethanol | 3.12 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight312.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.2mL | 16mL | 32.01mL |
| 5mM | 0.64mL | 3.2mL | 6.4mL |
| 10mM | 0.32mL | 1.6mL | 3.2mL |
| 50mM | 0.06mL | 0.32mL | 0.64mL |
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