Biological Activity
High affinity and selective adenosine A3 receptor agonist (Ki values are 1.1, 327, 1230 and > 30,000 nM for human A3, A1, A2A and A2B receptors respectively).
Compound Libraries
HEMADO is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 361.4 |
| Formula | C17H23N5O4 |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 403842-38-6 |
| PubChem ID | 10981286 |
| InChI Key | KOCIMZNSNPOGOP-IWCJZZDYSA-N |
| Smiles | O[C@@H]1[C@@H](CO)O[C@@H](N(C=N3)C2=C3C(NC)=NC(C#CCCCC)=N2)[C@@H]1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.14 | 100 | |
| ethanol | 36.14 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 361.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.77 mL | 13.84 mL | 27.67 mL |
| 5 mM | 0.55 mL | 2.77 mL | 5.53 mL |
| 10 mM | 0.28 mL | 1.38 mL | 2.77 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Klotz et al (2006) [3H]HEMADO- a novel tritated agonist selective for the human adenosine A3-receptor. Eur.J.Pharmacol. 556 14 PMID: 17126322
Volpini et al (2002) N6-Alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A3 receptor and a starting point for searching A2B ligands J.Med.Chem. 45 3271 PMID: 12109910
Keywords: HEMADO, supplier, High, affinity, selective, A3, agonists, Receptors, adenosines, Adenosine, A3, Receptors, Adenosine, A3, Receptors, Tocris Bioscience
