Tocris/NU 7441/3712/50/50毫克-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/NU 7441/3712/50/50毫克

Tocris/NU 7441/3712/50/50毫克

商品编号： 3712/50

品牌： Tocris Bioscience

市场价： ¥16500.00

美元价： 9900.00

产地：美国(厂家直采)

公司：

产品分类：其它酶

公司分类： Other_enzymes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:PotentandselectiveDNA-PKinhibitor

AlternativeNames:KU57788

ChemicalName:8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveDNA-PKinhibitor(IC₅₀=14nM).SelectiveforDNA-PKoverarangeofkinasesincludingmTOR,PI3-K,ATMandATR.Potentiatestheeffectsofdoxorubicin(Cat.No.2252)andetoposide(Cat.No.1226)invitroandetoposideinvivo.AlsoenhancesCRISPR-Cas9-mediatedhomology-directedrepair(HDR)efficiency2to3-fold,anddecreasesnonhomologousend-joining(NHEJ)frequency~40%.

TechnicalData

M.Wt	413.49
Formula	C₂₅H₁₉NO₃S
Storage	Storeat+4°C
Purity	≥99%(HPLC)
CASNumber	503468-95-9
PubChemID	11327430
InChIKey	JAMULYFATHSZJM-UHFFFAOYSA-N
Smiles	O=C1C3=C(C(C4=CC=CC5=C4SC6=C5C=CC=C6)=CC=C3)OC(N2CCOCC2)=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	2.07	5mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight413.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.42mL	12.09mL	24.18mL
5mM	0.48mL	2.42mL	4.84mL
10mM	0.24mL	1.21mL	2.42mL
50mM	0.05mL	0.24mL	0.48mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

TechnicalData

SolubilityData

PreparingStockSolutions

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