Biological Activity
Selective TrkB receptor agonist. Protects neurons from excitotoxicity. Protects retinas from light-induced retinal degeneration (LIRD) in vivo. Blood brain barrier and blood-retinal barrier penetrant.
Technical Data
| M. Wt | 301.34 |
| Formula | C16H19N3O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 314054-36-9 |
| PubChem ID | 5012758 |
| InChI Key | ZIMKJLALTRLXJO-UHFFFAOYSA-N |
| Smiles | OC1=CC=C2NC=C(C2=C1)CCNC(C3CCCNC3=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.13 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 301.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.32 mL | 16.59 mL | 33.19 mL |
| 5 mM | 0.66 mL | 3.32 mL | 6.64 mL |
| 10 mM | 0.33 mL | 1.66 mL | 3.32 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Setterholm et al (2015) Gram-scale, chemoselective synthesis of N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide (HIOC) Tetrahedron Lett. 56 3413 PMID: 26028783
Shen et al (2012) N-acetyl serotonin derivatives as potent neuroprotectants for retinas Proc.Natl.Acad.Sci.USA 109 3540 PMID: 22331903
Keywords: HIOC, supplier, Selective, TrkB, receptor, agonists, agonism, excitotoxicity, retinal, degeneration, blood, brain, barrier, BBB, neuroprotectant, Trk, Receptors, Trk, Receptors, Tocris Bioscience
