BiologicalActivity
Potent,irreversibleinhibitorofErbB2(HER2)andEGFR(IC50valuesare33and34nMrespectively).Suppressesligand-inducedEGFRautophosphorylationandcellproliferationinNCI-H1975cellscontainingL858RandT790Mmutations.CircumventsmechanismsofresistancetoIressa(Cat.No.3000)innon-small-celllungcancercells.
CompoundLibraries
HKI357isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 574.05 |
| Formula | C31H29ClFN5O3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 848133-17-5 |
| PubChemID | 11238512 |
| InChIKey | NERXPXBELDBEPZ-RMKNXTFCSA-N |
| Smiles | O=C(/C=C/CN(C)C)NC1=C(OCC)C=C(N=CC(C#N)=C2NC3=CC=C(OCC4=CC=CC(F)=C4)C(Cl)=C3)C2=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 57.4 | 100 | |
| ethanol | 14.35 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight574.05.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.74mL | 8.71mL | 17.42mL |
| 5mM | 0.35mL | 1.74mL | 3.48mL |
| 10mM | 0.17mL | 0.87mL | 1.74mL |
| 50mM | 0.03mL | 0.17mL | 0.35mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
本网站将在规定时间内给予删除等相关处理。
