Biological Activity
Humanin analog; increases glucose stimulated insulin secretion and glucose metabolism in vivo and in vitro. Also enhances glucose sensing in βTC3 cells and lowers blood glucose in Zucker diabetic fatty rats. Prevents endothelial dysfunction and delays progression of atherosclerosis in vivo.
Technical Data
| M. Wt | 2581.13 |
| Formula | C112H198N34O31S2 |
| Sequence | MAPRGASCLLLLTGEIDLPVKRRA |
| Storage | Store at -20°C |
| CAS Number | 1093111-54-6 |
| PubChem ID | 90489015 |
| InChI Key | OQIJKOVTOUEJGW-VFDWMCQBSA-N |
| Smiles | [H]N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 2581.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.39 mL | 1.94 mL | 3.87 mL |
| 5 mM | 0.08 mL | 0.39 mL | 0.77 mL |
| 10 mM | 0.04 mL | 0.19 mL | 0.39 mL |
| 50 mM | 0.01 mL | 0.04 mL | 0.08 mL |
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References
References are publications that support the products' biological activity.
Kuliawat et al (2013) Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell. FASEB J. 27 4890 PMID: 23995290
Muzumdar et al (2009) Humanin: a novel central regulator of peripheral insulin action. PLoS One. 4 e6334 PMID: 19623253
Oh et al (2011) Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice. Atherosclerosis. 219 65 PMID: 21763658
Keywords: HNGF6A, supplier, Alzheimer's, disease, insulin, diabetes, β, cells, humanin, endothelial, dysfunction, atherosclerosis, humanin, analogue, HN, beta, analog, Insulin, and, Insulin-like, Receptors, Insulin, and, insulin-like, Receptors, Insulin, and, insulin-like, Receptors, Tocris Bioscience
