Biological Activity
Potent and selective bradykinin B2 receptor antagonist (pA2 = 9.04). Also inhibits aminopeptidase N (Ki = 9.1 μM).
Technical Data
| M. Wt | 1304.52 |
| Formula | C59H89N19O13S |
| Sequence |
RRPXGXSXXR (Modifications: Arg-1 = D-Arg, X-4 = Hyp, X-6 = Thi, X-8 = Tic, X-9 = Oic) |
| Storage | Store at -20°C |
| CAS Number | 130308-48-4 |
| PubChem ID | 90488794 |
| InChI Key | QURWXBZNHXJZBE-JNFYKTHFSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@H](CC1=CC=CS1)C(=O)N[C@@H](CO)C(=O)N1CC2=C(C[C@@H]1C(=O)N1C3CCCCC3C[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1304.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.77 mL | 3.83 mL | 7.67 mL |
| 5 mM | 0.15 mL | 0.77 mL | 1.53 mL |
| 10 mM | 0.08 mL | 0.38 mL | 0.77 mL |
| 50 mM | 0.02 mL | 0.08 mL | 0.15 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Hock et al (1991) Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br.J.Pharmacol. 102 769 PMID: 1364851
Feletou et al (1994) Agonistic and antagonistic properties of the bradykinin B2 receptor antagonist, Hoe 140, in isolated blood vessels from different species. Br.J.Pharmacol. 112 683 PMID: 8075888
Bawolak et al (2006) The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors. Eur.J.Pharmacol. 551 108 PMID: 17026984
Keywords: HOE 140, supplier, Potent, selective, B2, antagonists, Receptors, Bradykinin, HOE140, Icatibant, Bradykinin, Receptors, Bradykinin, Receptors, Tocris Bioscience
