Biological Activity
Orally active and specific inhibitor of human hematopoietic prostaglandin D synthase (H-PGDS) (IC50 = 6 μM). Antiallergic and anti-inflammatory; displays antiasthmatic activity and potent antihistaminic properties in vivo.
Technical Data
| M. Wt | 377.48 |
| Formula | C22H27N5O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 162641-16-9 |
| PubChem ID | 6540277 |
| InChI Key | TZQGXAHOROZEKN-UHFFFAOYSA-N |
| Smiles | C1(CCCN2CCC(OC(C4=CC=CC=C4)C3=CC=CC=C3)CC2)=NN=NN1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.44 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 377.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.65 mL | 13.25 mL | 26.49 mL |
| 5 mM | 0.53 mL | 2.65 mL | 5.3 mL |
| 10 mM | 0.26 mL | 1.32 mL | 2.65 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
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References
References are publications that support the products' biological activity.
Aritake et al (2006) Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J.Biol.Chem. 281 15277 PMID: 16547010
Matsushita et al (1998) Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antihistaminic effects. Jpn.J.Pharmacol. 78 11 PMID: 9804057
Mohri et al (2006) Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher. J.Neurosci. 26 4383 PMID: 16624958
Keywords: HQL 79, supplier, HQL79, specific, hematopoietic, prostaglandin, D, synthase, HPGDS, inhibitors, inhibits, antiallergic, anti-inflammatory, Other, Synthases/Synthetases, Other, Synthases/Synthetases, Tocris Bioscience
