Biological Activity
Bioactive endogenous peptide substrate for endopeptidase 24.15 (ep24.15), neurolysin (ep24.16) and ACE. Ki values are 27.76, 3.43 and 1.87 μM respectively. Potent hypotensive in vivo. Also acts as a selective CB1 receptor inverse agonist. Displays antinociceptive activity in vivo.
Technical Data
| M. Wt | 1054.26 |
| Formula | C50H79N13O12 |
| Sequence | PVNFKLLSH |
| Storage | Store at -20°C |
| CAS Number | 1314035-51-2 |
| PubChem ID | 90488877 |
| InChI Key | JEXQOFXDPAGOQL-TZFLQVIRSA-N |
| Smiles | [H]N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1054.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.95 mL | 4.74 mL | 9.49 mL |
| 5 mM | 0.19 mL | 0.95 mL | 1.9 mL |
| 10 mM | 0.09 mL | 0.47 mL | 0.95 mL |
| 50 mM | 0.02 mL | 0.09 mL | 0.19 mL |
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References
References are publications that support the products' biological activity.
Rioli et al (2003) Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme. J.Biol.Chem. 278 8547 PMID: 12500972
Blais et al (2005) Hypotensive effects of hemopressin and bradykinin in rabbits, rats and mice. A comparative study. Peptides 26 1317 PMID: 16042973
Heimann et al (2007) Hemopressin is an inverse agonist of CB1 cannabinoid receptors. Proc.Natl.Acad.Sci.USA 104 20588 PMID:
Keywords: Hemopressin (human, mouse), supplier, Bioactive, endopeptidase, 2415, neurolysin, ACE, Angiotensin-Converting, Enzyme, Proteinases, Proteases, Substrates, activators, cannabinoids, receptors, CB1, inverse, agonists, antagonists, cb1r, CB1, Receptors, Other, Proteases, Enzyme, Substrates, /, Activators, CB1, Receptors, Tocris Bioscience
