BiologicalActivity
ATP-competitiveinhibitorofAuroraBkinase(IC50=250nM).Preventschromosomealignmentandsegregation;alsoinducespolyploidyandpreventshistoneH3-Ser10phosphorylation.Overridesthespindleassemblycheckpointandinducesmitoticexitinmonastrol-andtaxol-treatedHeLacells.
CompoundLibraries
HesperADInhydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 553.12 |
| Formula | C29H32N4O3S.HCl |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 422513-13-1 |
| PubChemID | 76968689 |
| InChIKey | XMYLEXZLFZAOQN-LXCLTORNSA-N |
| Smiles | O=C3/C(C2=CC(NS(CC)(=O)=O)=CC=C2N3)=C(C4=CC=CC=C4)NC1=CC=C(CN5CCCCC5)C=C1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 55.31 | 100 | |
| ethanol | 27.66 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight553.12.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.81mL | 9.04mL | 18.08mL |
| 5mM | 0.36mL | 1.81mL | 3.62mL |
| 10mM | 0.18mL | 0.9mL | 1.81mL |
| 50mM | 0.04mL | 0.18mL | 0.36mL |
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